Open AccessAssociation of Conventional and Exertional Coronary Heart Disease Risk Factors in 5,000 Apparently Healthy Men
Author(s) -
Davies Bruce,
Ashton William D.,
Rowlands Derek J.,
ElSayed Mahmoud,
Wallace Philip C.,
Duckett Ken,
Coley John,
Daggett Anne M.
Publication year - 1996
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960190405
Subject(s) - medicine , cardiology , coronary heart disease , disease , coronary artery disease , coronary disease
Background and hypothesis : The aim of this study was to define the prevalence of previously undetected coronary heart disease among asmptomatic males, aged 30‐65 years, by means of resting and exercise electrocardiography in conjunction with an analysis of conventional and exertional coronary risk factors. Methods : Between January 1985 and December 1989 we examined 5,000 clinically asymptomatic subjects. A detailed case history was obtained for each individual, followed by a complete physical examination, comprehensive blood (including lipid) profile, lung function tests, chest x‐ray, a resting 12‐lead electrocardiogram (ECG), and a maximal treadmill exercise ECG. Whenever possible, on‐line computerized respiratory analysis (Beckman Metabolic Measurement Cart) was carried out during the exercise tests. Conventional and exertional coronary heart disease risk factors were also recorded. Results : A total of 162 persons (3.2%) showed abnormal S‐T segment responses during the exercise or recovery period. Of these, 92 subjects underwent further investigations: coronary angiography (79), 201 thallium scanning (13), 201 thallium scanning followed by coronary angiography(7). Of the 86 patients who proceeded to cornoary angiography, 19 (22%) had either normal coronary artery anatomy or only insignificant disease. Among the 67 (78%) of patients with significant angiographically demonstrable disease, 26 received coronary artery bypass grafting, 7 underwent coronary angioplasty, and the remainder continued on medical management. Conclusions : These results are discussed in relation to a variety of conventional and exertional coronary risk factors.