Open AccessDobutamine‐induced transmural myocardial ischemia in a patient with mild coronary lesions
Author(s) -
Kardaras Fotis G.,
Bonou Maria S.,
Kardara Dimitra F.,
Kranidis Athanasios I.,
Sioras Elias P.,
Anthopoulos Lambros P.
Publication year - 1996
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960190214
Subject(s) - medicine , dobutamine , cardiology , hypokinesia , ischemia , angina , coronary artery disease , chest pain , stenosis , artery , myocardial ischemia , hemodynamics , myocardial infarction
A 70‐year‐old man was admitted for evaluation of retrosternal pain at rest. During infusion of dobutamine (25 μg/kg/min) the patient developed angina, ST‐segment elevation in the inferior leads, and echocardiographic hypokinesia in the inferior‐basal myocardial wall. Coronary angiography revealed insignificant (20‐30%) stenosis of the right coronary artery and a normal remaining tree. This case suggests that dobutamine may induce transmural myocardial ischemia in patients with mild coronary lesions, probably by producing occlusive coronary spasm on a substrate of arterial endothelial dysfunction.