Open AccessPlasma concentrations and coronary vasodilation after sublingual and intracoronary administration of isosorbide dinitrate
Author(s) -
Hoshio Akira,
Shirota Kinya,
Sasaki Norihito,
Doi Tetsuya,
Sawada Yoshihiro,
Fukuki Masaharu,
Miyakoda Hiroyuki,
Kotake Hiroshi,
Mashiba Hiroto
Publication year - 1995
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960181110
Subject(s) - isosorbide dinitrate , medicine , integrated services digital network , vasodilation , cardiology , anesthesia , hemodynamics , telecommunications , computer science
To investigate the relationship between plasma levels and coronary vasodilation after administration of isosorbide dinitrate (ISDN), the plasma concentration and diarneters of six segments of the left coronary artery were measured before and after sublingual (SL) ISDN (5 mg) and left intracoronary (IC) administration of ISDN (3 mg) in 12 patients. After SL‐ISDN, the systolic aortic pressure decreased with no significant concomitant changes in heart rate or diastolic aortic pressure. After IC‐ISDN, all hemodynamic parameters showed significant changes, and these were greater after IC‐ISDN than those after SL‐ISDN. The individual mean vasodilation of six segments induced by SL‐ and IC‐ISDN, were 23± 9 and 35± 11% (p<0.01), respectively. Before SL‐ISDN, ISDN was not detected in plasma. After SL‐ and IC‐ISDN, however, the plasma values of the ISDN were 36.1± 53.3 and 101.5± 90.0 ng/ml (p<0.01), respectively. Thus, both coronary vasodilative responses and plasma ISDN levels after IC‐ISDN were significantly greater than those after SL‐ISDN. However, neither the individual mean coronary vasodilation nor the hemodynamic changes correlated significantly with plasma ISDN levels. Consequently, with administration of the same dose, the coronary vasodilative response to ISDN did not correlate with plasma levels. Furthermore, IC‐ISDN dilates coronary arteries more effectively than SL‐ISDN.