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Clustered lipid droplets in the endomyocardial biopsies from a patient with neuroleptic malignant syndrome
Author(s) -
Watanabe Kenichi,
Inomata Takayuki,
Miyakita Yasushi,
Masani Fumiaki,
Shibata Akira,
Izumi Tohru
Publication year - 1994
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960171112
Subject(s) - medicine , cardiogenic shock , neuroleptic malignant syndrome , haloperidol , pathology , lipid metabolism , cardiology , hyperlipidemia , diabetes mellitus , endocrinology , myocardial infarction , dopamine
Neuroleptic malignant syndrome is caused by serious adverse effects of antipsychotic agents and occurs only rarely. Endomyocardial biopsies documented unique clustered lipid droplets in a Japanese man with this disease. After administration of haloperidol, he had symptoms of high fever, respiratory dysfunction, and cardiogenic shock, and subsequently suffered from multiple organ failure. Fortunately, he was completely cured with intensive therapy. in the convulsant stage, left ventricular endomyocardial biopsies were performed that yielded the interesting discovery of unique clustered lipid droplets among the myofibrils. It was suggested that although the pathomechanism of neuroleptic malignant syndrome is unknown, this disease may be characterized by a lipid metabolic disorder of the cardiac muscle cell.

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