Open AccessOxidized LDL and atherogenesis: Relation to risk factors for coronary heart disease
Author(s) -
Grundy Scott M.
Publication year - 1993
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960161303
Subject(s) - medicine , coronary heart disease , diabetes mellitus , disease , cardiology , low density lipoprotein , risk factor , lipoprotein , atherosclerotic cardiovascular disease , cholesterol , ldl cholesterol , endocrinology
According to a new theory, a critical step in atherogenesis is oxidation of low‐density lipoprotein (LDL) within the arterial wall. Direct data supporting this theory are limited, but indirect evidence suggests that oxidized LDL plays a role in atherogenesis. An important question is whether the LDL‐oxidation hypothesis conforms to what is known about other risk factors for coronary heart disease (CHD), such as hypertension, smoking, low high‐density lipoprotein (HDL) levels, and diabetes mellitus. Perhaps a unified theory of atherogenesis could be formulated if these risk factors exert their atherogenic actions in part by promoting, facilitating, or permitting the oxidation of LDL.