Open AccessLow‐dose dobutamine stress test for the evaluation of cardiac function using ultrafast computed tomography
Author(s) -
Yamaoka Osamu,
Fujioka Hideyuki,
Haque Tuhn,
Nakamura Yasuyuki,
Mitsunami Kenichi,
Kinoshita Masahiko,
Morita Rikushi,
Murata Kiyoshi
Publication year - 1993
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960160604
Subject(s) - medicine , ejection fraction , dobutamine , nuclear medicine , cardiac function curve , radiology , cardiology , hemodynamics , heart failure
High dose‐dobutamine (DOB) has been previously used as a pharmacological stress test to evaluate wall motion abnormalities. As a result, recent stress echocardiography with low‐dose DOB has been reported to be valuable for investigating stunned myocardium after thrombolysis. However, echocardiography requires an operator's skill and experience to evaluate wall motion abnormalities which are subjectively determined by the observer. In contrast, ultrafast computed tomography (UFCT) does not necessarily require extreme technical skill and experience. To evaluate the feasibility of stress UFCT with low‐dose DOB, we scanned 10 normal subjects along the short‐axis by 8‐slice‐multicine mode. After scanning at rest for baseline, we scanned during the administration of 4 and 8 m̈g/kg/min of DOB, respectively, for 5 min. Ejection fraction, contraction, and thickening were higher during 8 m̈g/kg/min of DOB than during 4 m̈g/kg/min of DOB and baseline, while the above values were higher during 4 m̈g/kg/min of DOB than during baseline (p < 0.01). It was possible to detect changes of cardiac function and wall motion due to low‐dose DOB by UFCT. We therefore conclude that UFCT is a reliable modality for evaluating cardiac function and wall motion for low‐dose DOB stress test because of its excellent spatial and contrast resolution.