Open AccessCholesterol and lipoproteins: Beyond atherogenesis
Author(s) -
Kuhn Frederick E.,
Mohler III Emile R.,
Rackley Charles E.
Publication year - 1992
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960151207
Subject(s) - medicine , prostacyclin , fibrinolysis , pathogenesis , coagulation , lipid metabolism , cholesterol , platelet , vascular disease , endocrinology
Although much emphasis has been placed on the role of cholesterol and lipoproteins in atherosclerotic plaque formation, recent studies suggest that lipids have other vascular actions which may contribute to the pathogenesis of myocardial ischemia. These include deleterious effects of lipids on platelet and endothelial cell function, coagulation, fibrinolysis, and prostacyclin metabolism. The purpose of this report is to review recent data regarding the nonatherogenic effects of lipids and provide insight as to how lipid lowering might contribute to clinically important improvements in vascular biology.