Open AccessComparison of clinical, morphological, and prognostic features in hypertrophic cardiomyopathy between japanese and western patients
Author(s) -
Chikamori Taishiro,
Mckenna William J.,
Doi Yoshinori L.,
Akizawa Masashi,
Yonezawa Yoshihiro,
Ozawa Toshio
Publication year - 1992
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960151108
Subject(s) - medicine , hypertrophic cardiomyopathy , cardiology , left ventricular hypertrophy , cardiomyopathy , muscle hypertrophy , incidence (geometry) , ventricular tachycardia , heart failure , blood pressure , physics , optics
Abstract Apical hypertrophic cardiomyopathy appears to be more common in Japan than in the West. Explanations for this difference include variable methods and criteria for the diagnosis. To assess morphological, clinical, and prognostic differences, 45 consecutive Japanese and 45 age‐ and gender‐matched Western patients with hypertrophic cardiomyopathy were evaluated in two referral institutions by the same individuals. The diagnosis of hypertrophic cardiomyopathy was based on the echocardiographic demonstration of unexplained left ventricular hypertrophy. Patients were aged 8 to 64 years (mean 50); there were 66 males and 24 females. The pattern of left ventricular hypertrophy was similar in Japanese and Western patients: asymmetric septal 64 vs. 76%, concentric 22 vs. 13%, and apical 13 vs. 11% (p = NS). The incidence of an echocardiographic or Doppler calculated left ventricular gradient of >30mmHg was similar (11 vs. 18%; p = NS). The maximal left ventricular wall thickness was greater in Western patients (23 ± 7 vs. 20 ± 4 mm; p = 0.03), but was not different when adjusted for body surface area. Clinical features including incidence of family history and ventricular tachycardia during 24‐h ambulatory electrocardiography were similar. During follow‐up (4.9 ± 4.0 years for Western vs. 4.4 ± 2.0 years for Japanese), disease‐related mortality was worse in Western patients (p < 0.05; 10 versus 2 patients). This evaluation, using the same diagnostic methods and criteria, reveals a worse prognosis in Western patients despite a similar clinical and morphological spectrum of hypertrophic cardiomyopathy.