Open AccessLeft ventricular diastolic dysfunction in coronary artery disease: Effects of coronary revascularization
Author(s) -
Inoue Teruo,
Morooka Shigenori,
Hayashi Terumi,
Takayanagi Kan,
Sakai Yoshihiko,
Takabatake Yutaka
Publication year - 1992
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960150806
Subject(s) - medicine , cardiology , diastole , revascularization , angina , coronary artery disease , distension , artery , ejection fraction , myocardial infarction , blood pressure , heart failure
Left ventricular diastolic dysfunction was studied globally and regionally in patients with coronary artery disease, and the effects of coronary revascularization were evaluated. A total of 25 patients with angina pectoris who had a stenotic lesion (≥90%) in only left anterior descending branch underwent coronary revascularization [percutaneous transluminal coronary angioplasty (PTCA) in 13 patients and coronary artery bypass graft (CABG) in 12]. Nine patients with normal coronary artery were studied as controls. Left ventricular volume and radial axes were measured on serial frames of one cardiac cycle by cine left ventriculography. The radial axes were drawn from the left ventricular gravity to left ventricular wall at every 20°. Left ventricular filling fraction and distension rate of radial axes were calculated at the times of 25%, 50%, 75%, and 100% of diastolic period, 100% being end‐diastole. Although there were no significant changes of the systolic function by revascularization, the filling fraction increased from 11.2±2.6 to 14.5±3.5% (p<0.001) at 25% time of diastole, from 29.9±4.9 to 32.5±5.0% (p<0.05) at 50% time in the PTCA group, and from 11.8±3.7 to 13.4±3.8% (p<0.01) at 25% time in the CABG group. The distension rate of radial axis to the anterior wall also increased significantly at 25% and 50% time of diastole after revascularization, and the change was marked in the PTCA group. However, these increases did not apply to the control patients. The results showed that the global and regional left ventricular early diastolic dysfunctions in patients with angina pectoris was partially reversible by coronary revascularization.