Open AccessDiagnostic value of technetium‐99m‐MIBI as a myocardial perfusion imaging agent: Comparison of long and short intervals between rest and stress injections
Author(s) -
Magriñà Jordi,
Bosch Xavier,
Roig Eulàlia,
Lopez Francisco Navarro,
Garcia Alicia,
Pons Francesca,
Moragas Mercè,
Setoain Jordi
Publication year - 1992
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960150706
Subject(s) - medicine , nuclear medicine , coronary artery disease , myocardial perfusion imaging , perfusion , thallium , technetium , technetium tc 99m sestamibi , scintigraphy , cardiology , radiology , inorganic chemistry , chemistry
To assess the diagnostic value of technetium‐99m‐MIBI ( 99m Tc‐MIBI) as a myocardial perfusion imaging agent, and if rest and exercise scans could be performed on the same day, 21 patients with coronary artery disease were studied. Qualitative planar 201‐thallium ( 201 T1) scans, coronary angiography, or both were also performed (median between studies 11 days). In 10 patients an injection of 740 mBq of 99m Tc‐MIBI at stress was followed by a second injection of 740 mBq at rest 24 h later (long interval) (LI). In 11 patients injection of 370 mBq at rest was followed 3 h later by an injection of 740 mBq at stress (short interval) (SI). Exercise scans were performed to similar maximal work load (LI = 6.6±1.8 METs; SI = 6.3±1.7 METs; 201 T1 = 6.8±1.2 METs; p = NS) and double product (LI = 19551±7370; SI = 19900±6797; 201 T1 = 19965 ±5282; p = NS). Overall, 99m Tc‐MIBI and 201 T1 agreed in 92% of the patients tested and in 165 of 180 (92%) left ventricular segments in both 99m Tc‐MIBI protocols using short and long intervals between injections. In 15 patients with significant stenosis, 99m Tc‐MIBI correctly identified 13 patients (sensitivity of 87%). Thus, 99m Tc‐MIBI is a useful imaging agent with similar diagnostic value as 201 T1. In spite of its lack of myocardial redistribution, 99m Tc‐MIBI rest and exercise scans performed on the same day seem to have a similar concordance rate with 201 T1 as when performed on separate days.