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Catastrophic thrombus development despite systemic heparinization during coronary angioplasty: Possible relationship to nonionic contrast
Author(s) -
Doorey Andrew J.,
Stillabower Michael E.,
Gale Nancy,
Goldenberg Edward M.
Publication year - 1992
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960150213
Subject(s) - medicine , cardiology , thrombus , angioplasty , contrast (vision) , bivalirudin , percutaneous coronary intervention , myocardial infarction , artificial intelligence , computer science
Two cases of catastrophic thrombus formation during coronary angioplasty occurred shortly after the operators began using nonionic contrast. This occurred despite systemic heparinization, the adequacy of which was documented by activated clotting times (ACT). Both cases were resistant to balloon inflation and one was refractory to intracoronary thrombolysis. There is a considerable body of evidence documenting that low‐osmolality contrast media, especially those that are nonionic, have less anticoagulant effect than standard contrast media. Several reports have also been published suggesting possible relationships between nonionic contrast and intravascular thrombus formation during coronary angiography and angioplasty. These data are reviewed and recommendations made for utilization of these contrast media.

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