Open AccessChanges of diastolic function induced by cigarette smoking: An echocardiographic study in patients with coronary artery disease
Author(s) -
Stork T.,
Eichstädt H.,
Möckel M.,
Bortfeldt R.,
Hochrein H.,
Müller R.
Publication year - 1992
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960150205
Subject(s) - medicine , isovolumetric contraction , cardiology , diastole , coronary artery disease , nicotine , blood pressure
In 28 chronic smokers (11 women, 17 men, 53 ± 10 years old) with coronary artery disease (>75% stenosis), left ventricular (LV) relaxation and filling behavior was assessed before and after inhalation of 0.9 mg nicotine (1 cigarette) by echocardiography. The following acute nicotine‐mediated changes were noted (one‐sided Wilcoxon test): heart rate increased from 67 to 81 beats/min (p>.001); the early diastolic flow (E wave) integral decreased from 49 to 39 mm (p<.001); the late diastolic flow integral (A wave) increased from 36 to 41 mm (p<.01). Consecutively, the ratio between E and A wave flow integrals decreased from 1.4 to 0.9 (p<.001); the atrial contribution to LV filling rose from 42 to 53% (p<.001); and the isovolumetric relaxation period increased from 89 to 122 ms (p<.001). In cigarette smokers with coronary artery disease acute administration of nicotine hence causes a shift of mitral blood flow from early (E wave) to late (A wave) diastole and a prolongation of the isovolumetric relaxation time. Thus, cigarette smoking significantly affects LV diastolic function independently of its role as a risk factor for coronary atherosclerosis.