Open AccessBeta Receptor Derangement in Postinfarction Left Ventricular Perianeurysm Tissue
Author(s) -
Levett James M.,
Mcgrath Lynn B.,
Bianchi John M.
Publication year - 1991
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960141110
Subject(s) - medicine , derangement , cardiology , myocardial infarction , combinatorics , mathematics
The purpose of this study was to evaluate alterations in adrenergic receptor density in patients with postinfarction left ventricular aneurysms. Resected specimens from 4 patients with left ventricular aneurysm were studied using standard techniques to evaluate beta receptors, alpha receptors, and muscarinic receptors in the border zone, perianeurysm tissue, Only the beta receptors demonstrated up‐regulation around the aneurysm (p=0.0003). This indicates that infarction with aneurysm formation can alter adrenergic receptor density, which may affect cellular response and predispose to arrhythmogenesis.