Open AccessDifferent hemodynamic (24‐h ambulatory blood pressure monitoring) and renin‐inhibiting effect of a 1‐week treatment with enalapril and lisinopril
Author(s) -
Cocco G.,
Hari J.
Publication year - 1991
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960141105
Subject(s) - lisinopril , enalapril , medicine , blood pressure , ambulatory blood pressure , heart rate , hemodynamics , ambulatory , pharmacology , crossover study , placebo , cardiology , plasma renin activity , angiotensin converting enzyme , anesthesia , renin–angiotensin system , alternative medicine , pathology
Ambulatory blood pressure and heart rate monitoring were used for comparing the antihypertensive effect of a 1‐week treatment with enalapril and lisinopril 10 mg once daily (double‐blind crossover placebo‐controlled study). Twelve outpatients with mild to moderate hypertension were treated. Both drugs had a significant and identical hypotensive effect. Neither drug affected the diurnal rhythm of blood pressure or heart rate. Therefore the two drugs are equipotent antihypertensive agents. Both drugs inhibited ACE activity to a highly significant extent, but in this regard lisinopril was more effective than enalapril. However, lisinopril's greater ACE inhibition was not accompanied by a greater hypotensive effect. The clinical value of this difference is not yet established.