Open AccessImpaired left ventricular filling during ST‐segment depression provoked by dipyridamole infusion in patients with syndrome X
Author(s) -
Nadazdin Aleksandar,
Shahi Manjit,
Foale Rodney A.
Publication year - 1991
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960141009
Subject(s) - medicine , dipyridamole , chest pain , st depression , cardiology , depression (economics) , coronary artery disease , artery , st segment , myocardial infarction , economics , macroeconomics
The left ventricular filling and regional wall motion patterns were compared in 6 normal subjects, 20 patients with coronary artery disease, and 10 patients with syndrome X by means of Doppler and two‐dimensional echocardiography during high‐dose (0.9 mg/kg body weight in 10 min) dipyridamole infusion. During the procedure none of the normal subjects had chest pain or significant ST depression (>0.1 mV) whereas 10 of 20 patients with coronary artery disease had ST depression, 3 with chest pain. Six patients with syndrome X had ST depression, 5 with chest pain. Regional wall motion abnormalities were identified in 6 patients with coronary artery disease who had ST depression but none were detected in normals or in patients with syndrome X. Compared with normals (−2.1±3.5%) there was a significant difference in percentage decrease in the peak early filling velocity in patients with coronary artery disease and ST depression (−10.3±6.2%; p<0.01) and in patients with syndrome X and ST depression (−9.4±6.9%; p<0.05). These findings indicate that, in the presence of dipyridamole‐induced ST depression, patients with syndrome X have an abnormal left ventricular filling pattern similar to that observed in patients with coronary artery disease. This suggests that myocardial ischemia occurs in patients with syndrome X but the absence of regional wall motion abnormality suggests that it is diffuse.