Open AccessElevation of factor VII activity and mass in coronary artery disease of varying severity
Author(s) -
Suzuki Toshikazu,
Yamauchi Kazunobu,
Matsushita Tadashi,
Furumichi Takeo,
Furui Hirohiko,
Tsuzuki Jitsuki,
Saito Hidehiko
Publication year - 1991
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960140907
Subject(s) - factor vii , medicine , myocardial infarction , coronary artery disease , antithrombin , risk factor , cardiology , zymogen , coagulation , gastroenterology , endocrinology , biochemistry , heparin , chemistry , enzyme
The present study was undertaken to determine whether the extent of Factor VII elevation correlated with the severity of coronary artery disease and whether zymogen or activated Factor VII was responsible for this elevation. A group of 69 patients with coronary artery disease with old myocardial infarction was compared with 28 control subjects. The patient groups showed elevated levels of Factor VII procoagulant activity (FVII.C) and more markedly elevated Factor VII antigen (FVII:Ag) levels than the control group; therefore they had a decreased FVII:C to FVII:Ag ratio. The increased Factor VII level in the patient groups was caused by elevated Factor VII zymogen levels, and not by activated Factor VII. Since FVII:C levels strongly correlated with the titer of thrombin‐antithrombin III complexes in all patients, the hypercoagulable state accompanying severe coronary atherosclerosis seems to underlie the increase of FVII and TAT in the stable phase of myocardial infarction.