Open AccessAntithrombotic therapy in the coronary vein graft patient
Author(s) -
Israel Douglas H.,
Fuster Valentin,
Stein Bernardo,
Adams Philip C.,
Stein Bernardo,
Chesebro James H.
Publication year - 1991
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960140403
Subject(s) - medicine , artery , intimal hyperplasia , thrombosis , cardiology , antithrombotic , vein , coronary vein , surgery , coronary artery disease , occlusion , bypass grafting , pathogenesis , vascular disease , smooth muscle , coronary sinus
Coronary artery bypass grafting is an important therapeutic modality in the treatment of the patient with coronary artery disease; however, long‐term results are limited by the development of saphenous vein graft disease early and late after operation. The pathogenesis of early vein graft occlusion is primarily thrombotic, while that occurring later frequently involves thrombosis superimposed on intimal hyperplasia or vein graft atherosclerosis. We describe the role of various platelet inhibitors and anticoagulants in the prevention of saphenous vein graft occlusion following coronary artery bypass grafting.