Open AccessPacing‐induced myocardial ischemia does not affect the endothelial release of coagulant and fibrinolytic factors into the coronary circulation
Author(s) -
Gössinger H. D.,
Siostrzonek P.,
Jung M.,
Mösslacher H.,
Speiser W.,
Kyrle P. A.,
Heistinger M.,
Lechner K.
Publication year - 1991
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960140314
Subject(s) - medicine , cardiology , coronary sinus , ischemia , prostacyclin , plasminogen activator , coronary circulation , von willebrand factor , platelet , blood flow
Abstract The present study addresses the potential effects of pacing‐induced myocardial ischemia on the secretion of coagulant and fibrinolytic factors within the coronary circulation. In 6 patients undergoing programmed ventricular stimulation with repeated induction of clinical ventricular tachycardia, the coronary release of tissue‐type plasminogen activator (t‐PA) antigen, plasminogen activator inhibitor (PAI) capacity, von Willebrand factor antigen (WF: Ag), and prostacyclin (6‐keto‐PGF la) was measured. Blood samples were collected simultaneously from the ascending aorta and the coronary sinus at baseline and immediately after the induction of ventricular tachycardia. The occurrence of pacing‐induced myocardial ischemia was established by myocardial net lactate production. Myocardial ischemia was induced in every patient by repeated pacing trials. Pacing‐induced ischemia did not affect the coronary release of any of the above factors. Consequently, there was no alteration of transcardiac gradients of thrombin‐antithrombin complexes and D‐dimer. The present results indicate that pacing‐induced myocardial ischemia does not affect the release of coagulant and fibrinolytic endothelial factors or prostacyclin into the coronary circulation.