Open AccessThe efficacy and safety of quinapril in the treatment of moderate to severe and severe hypertension: Comparison to captopril
Author(s) -
Frishman William H.
Publication year - 1990
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960131406
Subject(s) - quinapril , captopril , medicine , hydrochlorothiazide , diuretic , regimen , angiotensin converting enzyme , ace inhibitor , blood pressure
Major studies comparing the efficacy and safety of quinapril and captopril in the treatment of moderate to severe or severe hypertension are reviewed. Given concurrently with hydrochlorothiazide 25 mg/day to patients with moderate to severe hypertension, quinapril 20–80 mg/day twice daily was found to be more effective than captopril 50–200 mg/day twice daily, and quinapril 10–40 mg/day once daily was found to be as effective as captopril 25–100 mg/day twice daily. Given as initial monotherapy to patients with severe hypertension, quinapril 10–40 mg/day twice daily was found to be as effective as captopril 50–200 mg/day twice daily. Quinapril was found to be well tolerated, both when administered against a diuretic background and when diuretic was added to a quinapril regimen.