Open AccessLeft ventricular diastolic function in normotensive adolescents with different genetic risk of hypertension
Author(s) -
Alli C.,
Avanzini F.,
Ditullio M.,
Mariotti G.,
Salmoirago E.,
Taioli E.,
Radice M.
Publication year - 1990
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960130210
Subject(s) - medicine , ventricle , cardiology , left ventricular hypertrophy , diastole , diastolic function , muscle hypertrophy , mitral valve , blood pressure
Abnormalities of the diastolic function of the left ventricle are the first sign of cardiac involvement in arterial hypertension. We have studied the diastolic function in a group of normotensive adolescents with confirmed family history of hypertension. M‐mode echocardiography was performed in 86 normotensive males aged 14‐19 years: 41 sons of at least one hypertensive parent (SHT) and 45 sons of normotensive parents (SNT). Cross‐sectional area of the left ventricle and left ventricular (LV) mass index were significantly greater in the SHT than in the SNT group (10.05 ± 1.84 vs. 8.9 ± 1.56 cm/m 2 , p < 0.01 and 129.3 < 29.3 vs. 109.23 ± 25.7 g/m 2 , p < 0.002, respectively). No significant difference between the two groups was observed in the indices of left ventricular diastolic function, except for mitral valve opening rate (463.51 ± 90.45 in SHT vs. 416.71 ± 78.84 mm/s in SNT; p ± 0.02). From the analysis of the subgroup of adolescents having left ventricular mass greater than the upper normal value, we observed that they showed mean time of rapid filling significantly longer than SNT: this could represent an early marker of the pathological character of such hypertrophy. Our results suggest that the higher LV mass observed in the SHT is not associated with chamber and myocardial stiffness abnormalities.