Open AccessIntravenous Labetalol for the Control of Hypertension Following Repair of Coarctation of the Aorta
Author(s) -
Bojar R. M.,
Weiner B.,
Cleveland R. J.
Publication year - 1988
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960110909
Subject(s) - medicine , labetalol , coarctation of the aorta , aorta , complication , anesthesia , cardiology , blood pressure , renin–angiotensin system , abdominal aorta
Paradoxical hypertension is a relatively common complication of surgical repair of coarctation of the aorta. An early phase of systolic hypertension has been ascribed to elevated levels of norepinephrine. Activation of the renin‐angiotensin system from sympathetic stimulation has been implicated in a later phase of systolic and diastolic hypertension that can result in mesenteric arteritis. The use of a rapidly acting, titratable intravenous alpha‐ and beta‐adrenergic blocker, such as labetalol hydrochloride, addresses both of these neurohormonal mechanisms. in the intravenous form, it would appear to be an excellent choice for the management of early postoperative hypertension and it can be converted to the oral form in cases of persistent hypertension. We report for the first time the use of labetalol in two young patients for the control of paradoxical hypertension following coarctation repair.