Open AccessHemodynamic effects of metoprolol and nifedipine in angina pectoris measured by isotope technique
Author(s) -
Boström P.Å.
Publication year - 1988
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960110114
Subject(s) - medicine , metoprolol , nifedipine , angina , hemodynamics , cardiology , anesthesia , calcium , myocardial infarction
In order to evaluate the therapeutic effects of metoprolol, nifedipine, and their combination, 11 patients with secondary angina pectoris and with thallium tomographic findings indicating coronary artery disease were studied before and after these three treatment regimes in a single‐blind cross‐over study. The therapeutic effect was measured by standardized working test and isotope angiocardiography, which enabled evaluation of left ventricular ejection fraction, stroke volume, and phase analysis of left ventricular contraction. Treatment with metoprolol and combination therapy increased work performance. Ejection fraction did not differentiate the treatment regimes, whereas stroke volume was significantly lower at work and heart rate higher at rest and at work during nifedipine treatment compared to either metoprolol or combination treatment (p<0.05). Cardiac output was significantly reduced during nifedipine and metoprolol treatment during work (p<0.05). Phase improved after all therapeutic regimes, but reached significance only during the metoprolol treatment period at rest (p<0.05).