Open AccessDistribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration
Author(s) -
Latini R.,
D'Aranno V.,
Barbieri E.,
Fabbri A.,
Zampieri P.,
Trevi G. P.,
Zardini P.
Publication year - 1987
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960101115
Subject(s) - amiodarone , medicine , autopsy , myocardial infarction , anesthesia , antiarrhythmic agent , cardiology , heart disease , atrial fibrillation
The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarction treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug.