Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration | Zendy

Latini R. | Zendy; D'Aranno V. | Zendy; Barbieri E. | Zendy; Fabbri A. | Zendy; Zampieri P. | Zendy; Trevi G. P. | Zendy; Zardini P. | Zendy

Open Access

Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration

Author(s) -

Latini R.,

D'Aranno V.,

Barbieri E.,

Fabbri A.,

Zampieri P.,

Trevi G. P.,

Zardini P.

Publication year - 1987

Publication title -

clinical cardiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.263

H-Index - 72

eISSN - 1932-8737

pISSN - 0160-9289

DOI - 10.1002/clc.4960101115

Subject(s) - amiodarone , medicine , autopsy , myocardial infarction , anesthesia , antiarrhythmic agent , cardiology , heart disease , atrial fibrillation

The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarction treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug.

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