Open AccessSerum myoglobin in detection of myocardial necrosis in patients with “coronary insufficiency”
Author(s) -
Almog C.,
Isakov A.,
Burke M.,
Shapira I.,
Ayalon D.
Publication year - 1987
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960100510
Subject(s) - myoglobin , medicine , cardiology , myocardial infarction , necrosis , acute coronary syndrome , chemistry , organic chemistry
Myoglobin, an oxygen‐binding protein, is synthesized exclusively in striated and cardiac muscle, and is normally found in blood. Serum myoglobin determination has been used in the diagnosis of acute myocardial infarction. Experimental work has shown that myoglobin is released only after muscular necrosis. This prospective study included 101 patients: 62 with acute coronary insufficiency, 16 with acute myocardial infarction, and 23 controls. In all the patients with infarction the serum myoglobin levels were elevated. None of the controls showed serum myoglobin above normal. In patients with coronary insufficiency the peak serum myoglobin ranged from normal to 280 ng/ml. Half of all the patients with coronary insufficiency had a significant elevation of serum myoglobin (p<0.001). The obvious explanation of this finding is that myocardial necrosis to some extent develops in cases of so‐called coronary insufficiency. Furthermore, this study confirms previous findings that serum myoglobin assessment constitutes a very early marker of myocardial damage.