Open AccessAsynergy and left ventricular performance in dilative cardiomyopathy
Author(s) -
Zucchi R.,
Barsotti A.,
Mariotti R.,
Biadi O.,
Balbarini A.,
Mariani M.
Publication year - 1987
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960100305
Subject(s) - asynergy , medicine , cardiology , ejection fraction , cardiomyopathy , asynchrony (computer programming) , regurgitation (circulation) , heart failure , radionuclide ventriculography , computer network , asynchronous communication , computer science
The purpose of this work was to evaluate the presence and importance of asynergy in dilative cardiomyopathy. A semiautomatized analysis of left ventriculograms was performed in 18 cases, the morphology of longitudinal and transverse axes time‐length curves was evaluated, and mathematical indices of asynchrony and hypokinesis were defined. Ten normal subjects and 9 patients affected by aortic regurgitation were used as controls. In dilative cardiomyopathy, anomalous (polyphasic) time‐length curves were present in 55% of the cases, while they were absent in aortic regurgitation and in all normal subjects but one. In addition, the asynchrony index was slightly increased and the hypokinesis index significantly increased (28.8$$7.2% vs. 17.8$$7.1%, p<0.001). A negative correlation existed between the asynchrony index and the ejection fraction (r= −0.483, p<0.05) and both the ejection fraction and the maximum normalized velocity of contraction were reduced in the patients with the anomalous curves (29.7$$6.9% vs. 46.0$$11.5%, p<0.01; 1.66$$0.52 s −1 vs. 2.86$$1.33 s −1 , p<0.02). It was concluded that asynergy, and especially asynchrony, is frequent in dilative cardiomyopathy and it is strongly associated with a major impairment of overall left ventricular function.