Open AccessVariable neurohumoral and hemodynamic responses to exercise in patients with exertional angina: Influence of the severity of coronary artery disease
Author(s) -
Fujita T.,
Ajisaka R.,
Matsumoto R.,
Iida K.,
Iida K.,
Sugishita Y.,
Ito I.,
Takeda T.,
Akisada M.
Publication year - 1987
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960100205
Subject(s) - medicine , cardiology , angina , coronary artery disease , hemodynamics , blood pressure , heart rate , heart failure , rate pressure product , disease , myocardial infarction
To assess neurohumoral and hemodynamic responses to exercise in patients with exertional angina, we measured plasma norepinephrine (NE) concentrations in 23 patients with exertional angina (with no heart failure) and compared the results with their coronary arteriographic findings. The 23 patients were divided into two groups: 14 cases with multiple vessel disease (MVD) and 9 cases with one‐vessel disease. At resting state there were no significant differences between the two groups in levels of NE. At maximal exercise there were no significant differences between the groups in increases of heart rate, blood pressure, and rate‐pressure product, but exercise‐induced increase of plasma NE (%) was significantly larger in MVD (131.6 ± 95.4%) (mean±SD) than in one‐vessel disease (69.0±45.3%) (p<0.01). In conclusion, plasma NE responses to exercise differ between patients with multiple vessel disease and patients with one‐vessel disease.