Open AccessComparative effects of calcium‐channel blockers and beta‐adrenergic blocker on early diastolic time intervals and a‐wave ratio in patients with hypertrophic cardiomyopathy
Author(s) -
Doiuchi J.,
Hamada M.,
Kokubu T.,
Ito T.
Publication year - 1987
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960100106
Subject(s) - medicine , calcium channel blocker , hypertrophic cardiomyopathy , calcium channel , cardiology , diastole , beta blocker , heart rate , adrenergic , heart failure , calcium , blood pressure , receptor
To compare the effects of calcium‐channel blockers with those of beta‐adrenergic blockers in patients with hypertrophic cardiomyopathy (HCM), diastolic time intervals (IIA‐O time, from the second heart sound to the O point of apexcardiogram, IIA‐MVO time, from IIA to the mitral valve opening, and MVO‐O time, from the MVO to the O point of apexcardiogram), and A‐wave ratio measured from apexcardiogram were evaluated before and after more than three months of treatment. In both groups, heart rate significantly decreased after treatment. The IIA‐MVO time was not affected by either drug. The IIA‐O and the MVO‐O times were significantly shortened by calcium‐channel blockers (from 234.6±77.4 ms to 204.6±39.2 ms; p<0.01, and from 133.1±66.4 ms to 100.3±34.0 ms; p<0.01, respectively). However, they were not affected by beta‐adrenergic blocker. A‐wave ratio significantly decreased after calcium‐channel blockers (from 18.0±9.8% to 13.7±7.3%; p<0.01) and beta‐adrenergic blocker (from 21.7±12.6% to 17.2±8.0%; p<0.01). From these observations, it is suggested that calcium‐channel blockers improved the early diastolic filling rate, whereas beta‐adrenergic blocker did not affect it. It is concluded that the effects of calcium‐channel blockers and beta‐adrengergic blocker on early diastolic time intervals were different in patients with HCM.