Open AccessEffect of nifedipine on dipyridamole thallium‐201 myocardial scintigraphy
Author(s) -
Bonaduce D.,
Morgano G.,
Caico V.,
Breglio R.,
Condorelli M.,
Salvatore M.,
Muto P.
Publication year - 1986
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960090610
Subject(s) - dipyridamole , nifedipine , medicine , thallium , angina , heart rate , cardiology , antagonist , anesthesia , calcium , blood pressure , myocardial infarction , inorganic chemistry , chemistry , receptor
The effect of a calcium antagonist drug, nifedipine, on dipyridamole thallium‐201 images was assessed in 10 angina patients with positive dipyridamole test. Two dipyridamole thallium‐201 tests were performed, the first in basal conditions, the second after administration of 20 mg nifedipine. After dipyridamole, heart rate and double product increased respectively from 68.0±8.2 to 94.7±11.5 beats/min (p<0.01) and from 9459.5±1800.2 to 12,770.0±1864.7 mmHg x beats/min (p<0.01). Dipyridamole when infused after nifedipine induced an increase in heart rate from 74.2±7.16 to 88.8±5.6 beats/min (p<0.01) and in double product from 9650.5±1348.0 to 11,399.0±1146 mmHg x beats/min (p<0.05). Systolic and diastolic blood pressures were unmodified during the two studies. Segment scores were comparable before and after nifedipine. Thus, nifedipine does not worsen thallium‐201 myocardial images obtained during dipyridamole infusion, therefore, this test could provide an alternative to exercise thallium‐201 in patients receiving calcium antagonist drugs.