Open AccessFamilial hypercholesterolemia and HLA antigens
Author(s) -
Donadon V.,
Antonini CANTERIN A.,
De PAOLI P.,
Borean M.,
Villalta D.,
Zanata G.,
Santini G. F.
Publication year - 1986
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960090406
Subject(s) - medicine , familial hypercholesterolemia , human leukocyte antigen , etiology , disease , coronary heart disease , phenotype , immunology , antigen , genetics , cholesterol , gene , biology
Hereditary factors play an important role in the etiology and progression of coronary heart disease (CHD), most probably by causing the appearance and the levels of its risk factors. To investigate if there is a correlation between familial hypercholesterolemia and HLA system antigens, 25 subjects of 7 families with familial hypercholesterolemia were compared with 14 normocholesterolemic related subjects. Compared to normocholesterolemic kindreds, the familial hypercholesterolemic subjects have a significant increased HLA‐Bw 35 antigen and a lack of HLA‐A 1 . Therefore, the correlation found with some HLA system phenotypes improves our knowledge about familial hypercholesterolemia and aids in the identification of subjects affected with this disorder of lipid metabolism, which is one of the most important CHD risk factors.