Open AccessSinoatrial block induced by oral diltiazem
Author(s) -
Imamura T.,
Koiwaya Y.,
Nakamura M.
Publication year - 1986
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960090108
Subject(s) - diltiazem , medicine , sinoatrial node , cardiology , atrioventricular block , discontinuation , sick sinus syndrome , heart block , angina , sinus (botany) , electrocardiography , anesthesia , heart rate , myocardial infarction , blood pressure , calcium , botany , genus , biology
A 58‐year‐old man with variant angina who had no history suggestive of sinus node dysfunction experienced palpitation with pulse deficit after 8 days of diltiazem treatment, 240 mg per day. Electrocardiogram (ECG) revealed frequent occurrence of sinoatrial block. After discontinuation of diltiazem, an ambulatory ECG demonstrated gradual reduction of the occurrence of sinoatrial block, and no recurrence 8 hours after the last dose of the drug. One should note that diltiazem induces not only sinus node suppression and atrioventricular conduction disturbance, but also sinoatrial block.