Open AccessDifference in the response to isoproterenol between asymmetric septal hypertrophy and symmetric hypertrophy in patients with hypertrophic cardiomyopathy
Author(s) -
Iida K.,
Sugishita Y.,
Matsuda M.,
Yamaguchi T.,
Ajisaka R.,
Matsumoto R.,
Fujita T.,
Yukisada K.,
Ito I.
Publication year - 1986
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960090103
Subject(s) - medicine , hypertrophic cardiomyopathy , muscle hypertrophy , fractional shortening , cardiology , endocrinology , systole , myocardial hypertrophy , blood pressure , diastole
The response to isoproterenol was studied in 9 patients with hypertrophic cardiomyopathy (HCM) and asymmetric septal hypertrophy (ASH), 9 patients with HCM and symmetric hypertrophy (SH), and 9 normal controls (NC), using digitized M‐mode echocardiography. There was no significant difference in fractional shortening (FS) between ASH and SH, nor between SH and NC before isoproterenol infusion. During isoproterenol infusion, however, FS was significantly greater in ASH (60±6%) than in SH (53±7%) and NC (49±5%) (p<0.05, p<0.01, respectively), and normalized peak rate of change of left ventricular dimension during systole (pVs) was greater in ASH (7.7 ± 1.5/s) than in SH (5.2±0.8/s) and in NC (4.9±0.8/s) (p<0.001, p<0.001, respectively). This study shows that the response to isoproterenol of ASH differs from those of SH and of NC and suggests hypersensitivity of the beta‐adrenergic receptor system in ASH and the possibility that ASH is a different clinical entity than SH.