Open AccessElevated CK‐MB and CK‐BB in serum and tumor homogenate of a patient with lung cancer
Author(s) -
Lee B. I.,
Bach P. M.,
Horton J. D.,
Hickey T. M.,
Davis W. A.
Publication year - 1985
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960080409
Subject(s) - medicine , malignancy , isozyme , pathology , creatine kinase , lung cancer , carcinoma , pathological , lung , enzyme , biochemistry , biology
Elevated serum levels of creatine kinase (CK) were found in a patient with small‐(oat) cell carcinoma of the lung. Fractionation of the enzyme showed markedly elevated CK‐MB and CK‐BB isoenzymes. Clinical and subsequent pathological examination showed no evidence of infarction, inflammation, or tumor involvement of the heart; however, analysis of tumor tissue for CK showed predominance of CK‐MB and CK‐BB isoenzymes, thus implicating tumor as the source of the circulating levels of CK‐MB and CK‐BB. Our case is the first to document CK‐MB from neoplastic tissue homogenates, and illustrates that markedly elevated circulating levels of CK‐MB, or increased levels of CK‐MB in combination with CK‐BB may point away from a myocardial source, and toward the existence of a malignancy.