Open AccessThe lowering of daytime blood pressures with a single daily dose of acebutolol in ambulant hypertensives
Author(s) -
Mehta S. K.,
Goldberg A. D.,
Walsh J. T.
Publication year - 1985
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960080105
Subject(s) - medicine , acebutolol , daytime , blood pressure , anesthesia , pharmacology , atmospheric sciences , geology
Abstract Intra‐arterial blood pressure recordings were studied in 10 ambulant subjects with essential hypertension to evaluate the effect of a single daily dose of acebutolol. Blood pressures and heart rates, measured on a beat‐to‐beat basis were averaged over every hour, for the daytime, night‐time, and for the total 24 hours. Acebutolol significantly lowered the average daytime systolic pressure (160 to 142 mmHg, p = <0.01), diastolic pressure (78 to 66 dg, p = <0.01), and the heart rate (92 to 77 beats/min, p = <0.001). Significantly lower pressures were demonstrated up to 11 hours after the last dose of acebutolol. The effect on heart rate lasted up to 13 hours. The observed lowering of pressures and heart rate during the remaining 11 hours did not reach statistical significance.