Open AccessLithium causing a serious sinus‐node dysfunction at therapeutic doses
Author(s) -
Montalescot G.,
Levy Y.,
Farge D.,
Brochard L.,
Fantin B.,
Arnoux C.,
Hatt P. Y.
Publication year - 1984
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960071113
Subject(s) - medicine , lithium (medication) , sinus (botany) , therapeutic index , intensive care medicine , anesthesia , cardiology , psychiatry , drug , botany , biology , genus
Abstract The cardiovascular effects of lithium have been indexed in literature since 1900, most frequently in cases of intoxication. We recently studied the exceptional case of a patient showing a serious sinus node dysfunction during lithium treatment. The serum lithium levels were always within the therapeutic range. After two endocardial explorations and withdrawal of lithium, we found that the sinus node dysfunction was due to lithium and reversible after withdrawal of it. Some ignored dysfunctions could exist with a regularly controlled treatment.