Open AccessTime lapse from estimated onset of acute myocardial infarction to peak serum enzyme activity
Author(s) -
Herlitz J.,
Hjalmarson Å.,
Waldenströ J.
Publication year - 1984
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960070803
Subject(s) - medicine , myocardial infarction , creatine kinase , lactate dehydrogenase , enzyme assay , infarction , cardiology , enzyme , endocrinology , biochemistry , biology
In 581 patients with acute myocardial infarction (MI), the time lapse from estimated onset of infarction to estimated peak serum (S) enzyme activity was evaluated. Heat‐stable lactate dehydrogenase (LD; E.C. 1.1.1.27) was analyzed every 12 h for 48–108 h after arrival in hospital (n =581) and creatine kinase (CK; E.C. 2.7.3.2.; n=224), and creatine kinase subunit B (CK‐B; n=211) were analyzed every 6 h for 48 h. Peak S‐LD was observed between 14 and 110 h after estimated onset of MI (mean 46.6±0.6 h), peak S‐CK was observed between 8 and 58 h (mean 25.0±0.6 h), and peak S‐CK‐B was also observed between 8 and 58 h (mean 22.8 ±0.7 h) after onset. In 86% of patients, peak LD was reached within 60 h after onset of MI, in 78%, peak CK was reached within 30 h, and in 82%, peak CK‐B was observed within 30 h after onset of MI. A weak correlation was found between duration of pain and time lapse to S peak enzyme activity (r=0.25–0.27; p<0.001), while there was no correlation between S peak activity and time lapse from onset of MI to S peak activity. It is concluded, that although in the majority of patients with MI, peak serum‐enzyme activity is reached within a predictable amount of time after estimated onset of MI there is wide variation, difficult to establish from the clinical course, among individual patients.