Open AccessMitral valve prolapse related to geometrical changes of the heart in cases of progressive muscular dystrophy
Author(s) -
Yazawa Y.
Publication year - 1984
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960070403
Subject(s) - medicine , ventricle , mitral valve prolapse , cardiology , thorax (insect anatomy) , mitral valve , left atrium , anatomy , atrial fibrillation
The significance of geometrical changes of the heart for the development of mitral valve prolapse (MVP) was studied by echocardiograms and chest x‐ray films in 58 cases of progressive muscular dystrophy (PMD). The incidence of MVP was significantly higher (p<0.001) incases where the thoracic spine was straight or lordotic compared with cases of kyphotic thoracic spine. The flattening of the thorax associated with deformation of the thoracic spine was correlated with the left atrial dimension and left ventricular dimension (r=0.62, r=0.37, respectively; p<0.001), and MVP developed predominantly in cases with flattened thorax and small left atrial or left ventricular dimensions. The left atrial and left ventricular dimensions were significantly smaller in cases with MVP compared to cases without MVP (p<0.001, p<0.005, respectively). When both the left atrial and the left ventricular dimension shortened to certain levels, MVP was observed in almost all cases. From these results, it was suggested that the portion from the left atrium to the left ventricle was pressed by the forward bending of the thoracic spine, and the subsequent geometrical changes of the mitral ring and the left ventricle could produce redundancy of the chorda tendinea of the mitral valve, resulting in the occurrence of MVP.