Open AccessA Double‐Blind Study of Oxprenolol Once and Twice Daily in Hypertensive Patients
Author(s) -
Glazer N.,
Friedman B.,
Gerlings J. E.,
Gross S.,
Lowney C.,
Solomon R.
Publication year - 1983
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960060804
Subject(s) - medicine , tolerability , oxprenolol , blood pressure , regimen , supine position , adverse effect , essential hypertension , anesthesia , randomized controlled trial
In a randomized double‐blind study of 175 patients with mild‐to‐moderate hypertension, oxprenolol hydrochloride (160‐480 mg) given once daily was compared with the same drug given twice daily for efficacy, safety, and tolerability. Of these patients, 123 (58 receiving the once daily regimen and 65 receiving the twice daily regimen) were included in the analysis of efficacy. Both groups showed similar significant (p<0.01) reductions in mean blood pressure during the 6‐week titration period and for the remainder of the trial. A comparison of mean standing diastolic blood pressure and supine systolic and diastolic blood preses showed no significant difference between groups during the fixed dosage period. The number of patients reporting adverse experiences was not significantly different for the two regimens. Plasma triglycerides increased in both groups, but there were no other laboratory abnormalities related to treatment. This study shows that oxprenolol given once daily is effective, safe, and well tolerated in the treatment of mild‐to‐moderate hypertension.