Open AccessChromatin changes of endothelial cells in umbilical arteries in smokers
Author(s) -
Asmussen I.
Publication year - 1982
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960051206
Subject(s) - medicine , pathological , chromatin , nucleus , cell nucleus , pathology , endothelium , anatomy , endocrinology , genetics , biology , dna , psychiatry
Abstract Fine granular spots within the nucleus of endothelial cells have been demonstrated in umbilical arteries from newborns. These nuclear changes were predominantly found in vessels from newborns delivered by heavy smoking mothers (≥ 10 cigarettes per day) χ 2 = 8.28, p < 0.005. Similar nuclear changes have until now only been reported in man in relation to tumors or other pathological conditions. The vessels showed signs of increased cellular turnover compatible with the findings in experimental atherosclerosis. The nuclear changes thus could be interpreted as an alteration of nuclear activity.