Open AccessChanges in cardiovascular function induced by verapamil in healthy subjects and in patients with ischemic heart disease
Author(s) -
Vincenzi M.,
Morlino T.,
Allegri P.,
Barbieri E.,
Cappelletti F.,
Delio U.,
Ometto R.,
Maiolino P.
Publication year - 1981
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960040105
Subject(s) - medicine , verapamil , cardiology , contractility , inotrope , vascular resistance , heart rate , blood pressure , heart disease , disease , calcium
Alterations in cardiovascular function induced by the acute intravenous administration of verapamil (5 or 10 mg) in 52 patients (29 with ischemic heart disease and 23 without heart disease) were evaluated with use of invasive techniques (right and left heart catheterization, left ventricular cineangiography, and coronary arteriography). The most significant changes were represented by a decrease in systemic vascular resistance and systemic arterial pressure, and an increase in heart rate and cardiac output. Contractility indexes were not depressed in either group, and altered ventricular wall motion tended to improve to a slightly smaller degree than in patients treated with nitroglycerin. The use of verapamil in patients with ischemic heart disease appears to be safe, and concern about the negative inotropic influences in humans no longer seems justified.