Open AccessMyocardial imaging with extractable cations and inert tracers: The effects of flow and metabolism
Author(s) -
Selwyn A. P.,
Fox K.,
Shillingford J. P.
Publication year - 1978
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960010202
Subject(s) - perfusion , medicine , thallium , blood flow , nuclear medicine , krypton , coronary circulation , cardiology , chemistry , inorganic chemistry , xenon , organic chemistry
The physical and biological properties of 201 thallium (Tl) have been investigated and are discussed in this review. A new technique using the ultra‐short lived 81m krypton ( 81m Kr) as a continuous infusion into the aortic root in dogs and man is described. This provides a dynamic assessment of changes in regional myocardial perfusion. Experiments using 201 Tl and 81m Kr in dogs have shown that regional decreases in myocardial perfusion alone cannot be detected in images of the heart using 201 Tl. The effects of perfusion and a variety of factors on the energy dependent cellular uptake of 201 Tl are discussed as being of primary importance in changing the regional myocardial distribution of this tracer. The constant infusion of 81m Kr in patients with anginal chest pain provides continuous measurement of regional myocardial perfusion in high spatial resolution images. This dynamic method provides a physiological assessment of stenosed coronary arteries at rest and during stress.