Open AccessElevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina: An intravascular ultrasound study
Author(s) -
Hong MyeongKi,
Park SeongWook,
Lee Cheol Whan,
Choi SiWan,
Song JongMin,
Kang DukHyun,
Song JaeKwan,
Kim JaeJoong,
Park SeungJung
Publication year - 2002
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4950250506
Subject(s) - medicine , homocysteine , intravascular ultrasound , triglyceride , cardiology , cholesterol , ventricular remodeling , coronary atherosclerosis , coronary artery disease , high density lipoprotein , artery , endocrinology , myocardial infarction
Abstract Background : The relationship between plasma biologic markers and coronary artery remodeling is unknown. Hypothesis : Plasma biologic markers are associated with coronary artery remodeling. Methods : Preintervention intravascular ultrasound images were obtained in 44 patients with chronic stable angina. Plasma samples were collected 24 h before coronary intervention. The biologic markers included total cholesterol, low‐density lipoprotein (LDL) cholesterol, triglyceride, high‐density lipoprotein (HDL) cholesterol, lipoprotein(a) [LP(a)], C‐reactive protein (CRP), and homocysteine. The remodeling index (RI) was defined as a ratio of the (lesion/ proximal reference) external elastic membrane cross‐sectional area. Positive remodeling was defined as an RI > 1.05, negative remodeling as an RI < 0.95, and intermediate remodeling as an RI between 0.95 and 1.05. Results : Total cholesterol level (r = 0.092, p = 0.557), LDL cholesterol level (r = 0.123, p = 0.426), triglyceride level (r = 0.020, p = 0.901), HDL cholesterol level (r = 0.042, p = 0.789), LP(a) level (r = 0.062, p = 0.729), and CRP level (r = 0.266, p = 0.089) did not significantly correlate with the RI. However, the plasma homocysteine level positively correlated with the RI (r = 0.398, p = 0.008). The plasma homocysteine level was significantly lower in the lesions with negative remodeling and higher in the lesions with positive remodeling (10.8 ± 0.7 μmol/l in negative remodeling, 13.1 ± 0.6 μmol/l in intermediate remodeling, and 18.1 ± 2.8 μmol/l in positive remodeling, p = 0.021). Conclusions : Elevated homocysteine levels might be associated with coronary artery remodeling in patients with stable angina.