Open AccessInitiating ivabradine during hospitalization in patients with acute heart failure: A real‐world experience in China
Author(s) -
Liu YingXian,
Chen Wei,
Lin Xue,
Zhu YanLin,
Lai JingZhi,
Li JinYi,
Guo XiaoXiao,
Yang Jing,
Qian Hao,
Zhu YuanYuan,
Wu Wei,
Fang LiGang
Publication year - 2022
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.23880
Subject(s) - ivabradine , medicine , hazard ratio , ejection fraction , heart failure , cardiology , clinical endpoint , confidence interval , acute decompensated heart failure , retrospective cohort study , adverse effect , cardiac function curve , heart rate , randomized controlled trial , blood pressure
Background Initiating ivabradine in acute heart failure (HF) is still controversial. Hypothesis Ivabradine might be effective to be added in acute but hemodynamically stable HF. Methods A retrospective cohort of hemodynamically stable acute HF patients was enrolled from January 2018 to January 2020 and followed until July 2020. The primary endpoints were all‐cause mortality and rehospitalization for HF. Secondary endpoints included heart rate (HR), cardiac function measured by New York Heart Association (NYHA) class, and left ventricular ejection fraction (LVEF) and adverse events, which were compared between patients with or without ivabradine. Results A total of 126 patients were enrolled (50 males, median age 54 years, 81% with decompensated HF, median follow‐up of 9 months). In patients treated with ivabradine, although baseline HRs were higher than the reference group (96 vs. 80 bpm), they were comparable after 3 months; more patients tolerated high doses of β‐blockers (27% vs. 7.9%), improved to NYHA class I function (55.6% vs. 23.8%) and exhibited normal LVEFs (37.8% vs. 14.3%) than the reference group (all p < .05). Ivabradine was associated with a significant reduction of rehospitalization for HF than the reference group (25.4% vs.61.9%), with longer event‐free survival times (hazard ratio: 0.45, 95% confidence interval [CI]: 0.25–0.79), and was related with primary endpoints negatively (hazard ratio 0.51, 95% CI: 0.28–0.91) (all p < .05). Conclusion In patients with acute but hemodynamically stable HF, ivabradine may significantly reduce HR, improve cardiac function, and reduce HF rehospitalization.