Open AccessMetabolic syndrome and concomitant diabetes mellitus are associated with higher risk of cardiovascular comorbidity in patients with primary glomerular diseases: A retrospective observational study
Author(s) -
Xie Zhiyong,
Li Zhilian,
Dong Wei,
Chen Yuanhan,
Li Ruizhao,
Wu Yanhua,
Lin Ting,
Tao Yiming,
Liang Huaban,
Wang Wenjian,
Liu Shuangxin,
Ye Zhiming,
Shi Wei,
Liang Xinling
Publication year - 2020
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.23388
Subject(s) - medicine , comorbidity , concomitant , diabetes mellitus , metabolic syndrome , hyperuricemia , retrospective cohort study , renal function , risk factor , endocrinology , uric acid
Background Metabolic syndrome (MS) and diabetes mellitus (DM) are risk factors for cardiovascular diseases in general population. However, there was a paucity of studies investigating their impact in primary glomerular diseases (PGD). Hypothesis MS and concomitant DM are associated with higher risk of cardiovascular comorbidity in PGD. Methods In a retrospective observational design, we analyzed 3622 hospitalized adult PGD patients and compared the prevalence of cardiovascular comorbidity in non‐MS, MS with and without DM. Risk factors for cardiovascular comorbidity were identified using univariate and multivariate logistic regression. Results Among 3622 PGD patients, 308 (8.5%) cases accompanied with MS, including 180 (5.0%) patients with DM and 128 (3.5%) without DM. One hundred and sixty four (4.5%) cases coexisted with cardiovascular comorbidity. Patients with MS and concomitant DM exhibited a higher prevalence of cardiovascular comorbidity than those without MS stratified by estimated glomerular filtration rate and pathological types. Logistic regression showed that MS and concomitant DM (OR: 2.496, 95% CI: 1.600‐3.894, P < .001), older age (OR: 1.060, 95% CI: 1.047‐1.074, P < .001), male (OR: 1.536, 95% CI: 1.072‐2.200, P = .019), higher level of serum ti (OR: 1.002, 95% CI: 1.001‐1.003, P < .001), hyperuricemia (OR: 1.901, 95% CI: 1.327‐2.725, P < .001), idiopathic membranous nephropathy (OR: 2.874, 95% CI: 1.244‐6.640, P < .001) and focal segmental glomerulosclerosis (OR: 2.906, 95% CI: 1.147‐7.358, P < .001) were independently associated with a higher risk for cardiovascular comorbidity. Conclusions In PGD patients, MS and concomitant DM are associated with an increased risk for cardiovascular comorbidity. More evidence for the causal link between MS/DM and cardiovascular outcomes is needed to be clarified.