Open AccessGenetic association between plasminogen activator inhibitor‐1 rs1799889 polymorphism and venous thromboembolism: Evidence from a comprehensive meta‐analysis
Author(s) -
Huang Guangbin,
Wang Pan,
Li Tao,
Deng Xuejun
Publication year - 2019
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.23282
Subject(s) - medicine , odds ratio , confidence interval , meta analysis , plasminogen activator inhibitor 1 , gastroenterology , allele , deep vein , polymorphism (computer science) , thrombosis , venous thrombosis , plasminogen activator , genetics , gene , biology
Background Association between plasminogen activator inhibitor‐1 ( PAI‐1 ) rs1799889 polymorphism and venous thromboembolism (VTE) were explored by many previous studies, yet the findings of these studies were conflicting. Hypothesis PAI‐1 rs1799889 polymorphism may serve as a genetic marker of VTE. We aimed to better clarify the relationship between PAI‐1 rs1799889 polymorphism and VTE in a larger combined population by performing a meta‐analysis. Methods Literatures were searched in Pubmed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI). We used Review Manager to combine the results of individual studies. Results Forty‐eight studies involving 14 806 participants were eligible for inclusion. Combined results revealed that PAI‐1 rs1799889 polymorphism was significantly associated with VTE in Caucasians (dominant comparison: odds ratio [OR] 1.20, 95% confidence interval [CI] 1.09‐1.32; recessive comparison: OR 0.84, 95% CI 0.76‐0.94; allele comparison: OR 1.08, 95% CI 1.02‐1.15) and East Asians (dominant comparison: OR 1.60, 95% CI 1.17‐2.19; allele comparison: OR 1.53, 95% CI 1.21‐1.93). Further analyses obtained similar significant associations in these with deep vein thrombosis (DVT) and these with Factor V Leiden mutation. Conclusions Our findings supported that PAI‐1 rs1799889 polymorphism may serve as one of the predisposing factors of VTE in both Caucasians and East Asians, especially in these with DVT and these with Factor V Leiden mutation.