Open AccessBidirectional association between aortic dissection and atrial fibrillation: Findings from a huge national database
Author(s) -
Hu WeiSyun,
Lin ChengLi
Publication year - 2019
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.23223
Subject(s) - medicine , atrial fibrillation , hazard ratio , cohort , incidence (geometry) , propensity score matching , proportional hazards model , confidence interval , aortic dissection , cohort study , retrospective cohort study , aorta , physics , optics
Objective To explore the link between aortic dissection (AD) and atrial fibrillation (AF). Methods Using the National Health Insurance Research Database (NHIRD), cohorts were constructed for evaluating the incidence of AF in patients with AD (study 1) and the incident AD among AF patients (study 2) based on propensity matching analysis. Cox proportion hazard regression models were used to examine the effect of AD on the risk of AF, shown as hazard ratios (HRs) with 95% confidence intervals (CIs). Similar statistical procedures were used for study 2. Results The study 1 consisted of 11 813 patients in the AD cohort and 11 813 controls in the non‐AD cohort and the study 2 consisted of 190 494 patients in the AF cohort and 190 494 controls in the non‐AF cohort. The overall incidence density of AF was 1.32‐fold higher in the AD cohort than in the non‐AD cohort (11.1 and 8.3 per 1000 person‐years), with an adjusted HR (aHR) of 1.74 (95% CI = 1.53‐1.98). The AF cohort had 1.18‐fold higher incidence of AD than the non‐AF cohort (0.55 vs 0.47 per 1000 person‐years), with an aHR of 1.24 (95% CI = 1.07‐1.44). Conclusions Bidirectional association between AD and AF was shown for the first time in this study.