Open AccessIncreased risk of atrial fibrillation in patients with benign prostatic hyperplasia: A population‐based cohort study
Author(s) -
Hu WeiSyun,
Lin ChengLi
Publication year - 2018
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.23063
Subject(s) - medicine , hazard ratio , atrial fibrillation , propensity score matching , incidence (geometry) , proportional hazards model , cohort , benign prostatic hyperplasia (bph) , confounding , retrospective cohort study , cohort study , confidence interval , rate ratio , population , urology , prostate , cancer , physics , environmental health , optics
Objective The objective was to compare the rate of onset of atrial fibrillation (AF) in patients with benign prostatic hyperplasia (BPH) as compared with controls. Methods We performed a retrospective study on national health registry comparing the incidence of AF between a cohort of 15 670 BPH patients and a propensity‐matched cohort of 15 670 control patients. Univariable and multivariable Cox proportional hazards models were performed to estimate the hazard ratios (HR) and 95% confidence intervals (CI) of incident AF associated with BPH. A subgroup analysis was performed to evaluate the risk of AF among BPH patients whether they received a BPH surgery or not as compared with those without BPH. Results We found a 4.77 incidence rate per 1000 person‐years in the BPH group, compared to 3.76 in the control group. After controlling for the confounders, a significant association between BPH and risk of incident AF was shown with an adjusted HR = 1.19, 95% CI = 1.11‐1.28) and this association was attenuated once surgical intervention for BPH has been applied (adjusted HR = 0.86, 95% CI = 0.76‐0.97). Conclusions This study supported the notion that BPH is associated with greater AF occurrence.