Open AccessImpact of lung‐function measures on cardiovascular disease events in older adults with metabolic syndrome and diabetes
Author(s) -
Lee Hwa Mu,
Zhao Yanglu,
Liu Michael A.,
Yanez David,
Carnethon Mercedes,
Graham Barr R.,
Wong Nathan D.
Publication year - 2018
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.22985
Subject(s) - medicine , vital capacity , diabetes mellitus , quartile , metabolic syndrome , cardiology , heart failure , proportional hazards model , disease , obesity , lung function , confidence interval , lung , endocrinology , diffusing capacity
Background Individuals with metabolic syndrome (MetS) and diabetes (DM) are more likely to have decreased lung function and are at greater risk of cardiovascular disease (CVD). Hypothesis. Lung‐function measures can predict CVD events in older persons with MetS, DM, and neither condition. Methods We followed 4114 participants age ≥ 65 years with and without MetS or DM in the Cardiovascular Health Study. Cox regression examined the association of forced vital capacity (FVC) and 1‐second forced expiratory volume (FEV 1 ; percent of predicted values) with incident coronary heart disease and CVD events over 12.9 years. Results DM was present in 537 (13.1%) and MetS in 1277 (31.0%) participants. Comparing fourth vs first quartiles for FVC, risk of CVD events was 16% (HR: 0.84, 95% CI: 0.59–1.18), 23% (HR: 0.77, 95% CI: 0.60–0.99), and 30% (HR: 0.70, 95% CI: 0.58–0.84) lower in DM, MetS, and neither disease groups, respectively. For FEV 1 , CVD risk was lower by 2% (HR: 0.98, 95% CI: 0.70–1.37), 26% (HR: 0.74, 95% CI: 0.59–0.93), and 31% (HR: 0.69, 95% CI: 0.57–0.82) in DM. Findings were strongest for predicting congestive heart failure (CHF) in all disease groups. C‐statistics increased significantly with addition of FEV 1 or FVC over risk factors for CVD and CHF among those with neither MetS nor DM. Conclusions FEV 1 and FVC are inversely related to CVD in older adults with and without MetS, but not DM (except for CHF); however, their value in incremental risk prediction beyond standard risk factors is limited mainly to metabolically healthier persons.