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The short‐ and long‐term outcomes of percutaneous intervention with drug‐eluting stent vs bare‐metal stent in saphenous vein graft disease: An updated meta‐analysis of all randomized clinical trials
Author(s) -
Kheiri Babikir,
Osman Mohammed,
Abdalla Ahmed,
Ahmed Sahar,
Bachuwa Ghassan,
Hassan Mustafa
Publication year - 2018
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.22908
Subject(s) - medicine , mace , percutaneous coronary intervention , randomized controlled trial , stent , odds ratio , surgery , cardiology , coronary artery disease , hazard ratio , meta analysis , confidence interval , myocardial infarction
The use of drug‐eluting stents (DES) vs bare‐metal stents (BMS) in saphenous vein graft (SVG) lesions remains controversial. We conducted a meta‐analysis of all randomized clinical trials comparing the outcomes of DES with BMS in SVG percutaneous coronary interventions. A search of PubMed, Embase, the Cochrane Register of Controlled Trials, and Clinicaltrials.gov was performed for all randomized clinical trials. We evaluated the short‐ and long‐term clinical outcomes of the following: all‐cause mortality, major adverse cardiovascular events (MACE), definite/probable stent thrombosis, target lesion revascularization (TLR), and target‐vessel revascularization (TVR). From a total of 1582 patients in 6 randomized clinical trials, 797 had DES and 785 had BMS. Patients with DES had lower short‐term MACE, TLR, and TVR in comparison with BMS (odds ratio [OR]: 0.56, 95% confidence interval [CI]: 0.35–0.91, P  = 0.02; OR: 0.43, 95% CI: 0.19–0.99, P  = 0.05; and OR: 0.45, 95% CI: 0.22–0.95, P  = 0.04, respectively). However, there were no different outcomes for all‐cause mortality ( P  = 0.63) or stent thrombosis ( P  = 0.21). With long‐term follow‐up, there were no significant reductions of MACE ( P  = 0.20), TLR ( P  = 0.57), TVR ( P  = 0.07), all‐cause mortality ( P  = 0.29), and stent thrombosis ( P  = 0.76). The use of DES in SVG lesions was associated with lower short‐term MACE, TLR, and TVR in comparison with BMS. However, there were no significant differences with long‐term follow‐up.

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