Open AccessRationale and design of the long‐Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post–myocardial infarction patients (TIGRIS) study
Author(s) -
Westermann Dirk,
Goodman Shaun G.,
Nicolau José C.,
Requena Gema,
Maguire Andrew,
Chen Ji Yan,
Granger Christopher B.,
Grieve Richard,
Pocock Stuart J.,
Blankenberg Stefan,
Vega Ana Maria,
Yasuda Satoshi,
Simon Tabassome,
Brieger David
Publication year - 2017
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.22837
Subject(s) - medicine , myocardial infarction , coronary artery disease , observational study , clinical endpoint , unstable angina , disease , health care , revascularization , angina , stroke (engine) , intensive care medicine , quality of life (healthcare) , emergency medicine , cardiology , clinical trial , mechanical engineering , nursing , engineering , economics , economic growth
The long‐term progression of coronary artery disease as defined by the natural disease course years after a myocardial infarction (MI) is an important but poorly studied area of clinical research. The long‐Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post–myocardial infarction patients (TIGRIS) study was designed to address this knowledge gap by evaluating patient management and clinical outcomes following MI in different regions worldwide. TIGRIS ( ClinicalTrials.gov Identifier: NCT01866904) is a multicenter, observational, prospective, longitudinal study enrolling patients with history of MI 1 to 3 years previously and high risk of developing atherothrombotic events in a general‐practice setting. The primary objective of TIGRIS is to evaluate clinical events (time to first occurrence of any event from the composite cardiovascular endpoint of MI, unstable angina with urgent revascularization, stroke, or death from any cause), and healthcare resource utilization associated with hospitalization for these events (hospitalization duration and procedures) during follow‐up. Overall, 9225 patients were enrolled between June 2013 and November 2014 and are being followed in 369 different centers worldwide. This will allow for the description of regional differences in patient characteristics, risk profiles, medical treatment patterns, clinical outcomes, and healthcare resource utilization. Patients will be followed for up to 3 years. Here we report the rationale, design, patient distribution, and selected baseline characteristics of the TIGRIS study. TIGRIS will describe real‐world management, quality of life (self‐reported health), and healthcare resource utilization for patients with stable coronary artery disease ≥1 year post‐MI.