Open AccessQTc dispersion and Cornell duration product can predict 10‐year outcomes in hypertensive patients with left ventricular hypertrophy
Author(s) -
Djordjević Dragan B.,
Tasić Ivan S.,
Kostić Svetlana I.,
Stamenković Boja.,
Djordjević Aleksandar D.,
Lović Dragan B.
Publication year - 2017
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.22815
Subject(s) - medicine , left ventricular hypertrophy , cardiology , statistical significance , muscle hypertrophy , blood pressure
Background Persistent and adequate treatment of patients with arterial hypertension leads to more favorable disease outcome. Hypothesis Aside for the present left ventricular hypertrophy (LVH), there are other non‐invasive parameters which can represent additional predictors of unfavorable prognosis in patients with essential arterial hypertension during the 10‐year follow‐up. Methods A hypertensive group with LVH (124 patients; age 57.0 ± 8.0; 84 males and 40 females) was included in the study and examined noninvasively. Patients used regular medication therapy during the follow‐up period. Results During the 10‐year follow‐up period, unfavorable outcome was recorded for 40 (32.3%) patients. Patients with unfavorable outcome had higher baseline values of left ventricular mass index (178.9 ± 29.5 g/m 2 vs 165.5 ± 29.5 g/m 2 ; P < 0.05) and QTc dispersion (64.1 ± 24.7 ms vs 54.8 ± 19.4 ms; P < 0.05). Frequency of positive Cornell product was higher in the group of patients with unfavorable outcome (35% vs 22.2%; P < 0.01). Positive Lyon‐Sokolow score did not show statistical significance (25% vs 11.9%; P = 0.06). Cornell product (β = 0.234; P < 0.01) and QTc dispersion >65 ms (β = 0.184; P < 0.05) had prognostic significance in LVH (multiple regression analysis: R = 0.314, R = 0.099, adjusted R = 0.084, standard error of the estimate = 0.449, P < 0.05). Conclusions Patients with a positive Cornell product and larger QTc dispersion had more unfavorable 10‐year outcomes compared with other patients with LVH.